Cognitive Science

The latest breakthroughs, innovations, and cool happenings at the cutting edge of the world of cognitive science. Updated daily.

Loss of miR-369 Promotes Tau Phosphorylation by Targeting the Fyn and Serine/Threonine-Protein Kinase 2 Signaling Pathways in Alzheimer’s Disease Mice

IntroductionAlzheimer’s disease (AD) is a progressive neurodegenerative dementia with the key pathological hallmarks amyloid-beta deposition and neurofibrillary tangles composed of hyperphosphorylated tau. microRNAs (miRNAs) are small non-coding RNAs that contribute to the pathogenesis of AD. In this study, we investigated the effect of the loss of miR-369 on the phosphorylation of tau protein and the […]

Published on February 3, 2020

Prefrontal Consolidation and Compensation as a Function of Wearing Denture in Partially Edentulous Elderly Patients

BackgroundThe cognitive effects of wearing a denture are not well understood. This study was conducted to clarify the effects of denture use on prefrontal and chewing muscle activities, occlusal state, and subjective chewing ability in partially edentulous elderly individuals.MethodsA total of 16 partially edentulous patients were enrolled. Chewing-related prefrontal cortex and jaw muscle activities were […]

Published on February 3, 2020

The Decline in Intrinsic Connectivity Between the Salience Network and Locus Coeruleus in Older Adults: Implications for Distractibility

We examined functional connectivity between the locus coeruleus (LC) and the salience network in healthy young and older adults to investigate why people become more prone to distraction with age. Recent findings suggest that the LC plays an important role in focusing processing on salient or goal-relevant information from multiple incoming sensory inputs (Mather et […]

Published on February 3, 2020