Objective: To assess the association between low-density lipoprotein cholesterol (LDL-c) and risk of Alzheimer’s disease (AD).Methods: Embase, Pubmed, and Web of Science were searched until June 2019. Standard mean difference (SMD) with 95% confidence intervals (CI) was estimated using random-effects models.Results: Our meta-analysis of 26 studies revealed higher levels of LDL-c in AD than that […]

Objective: Mild cognitive impairment (MCI) is an important risk state for dementia, particularly Alzheimer’s disease (AD). Depression, anxiety, and apathy are commonly observed neuropsychiatric features in MCI, which have been linked to cognitive and functional decline in daily activities, as well as disease progression. Accordingly, the study’s objective is to review the prevalence, neuropsychological characteristics, […]

A traditional view of short-term working memory (STM) is that task-relevant information is maintained ‘online’ in persistent spiking activity. However, recent experimental and modeling studies have begun to question this long-held belief. In this review, we discuss new evidence demonstrating that information can be ‘silently’ maintained via short-term synaptic plasticity (STSP) without the need for […]