Parkinson’s disease (PD) is the second-leading cause of dementia and is characterized by a progressive loss of dopaminergic neurons in the substantia nigra alongside the presence of intraneuronal α-synuclein-positive inclusions. Therapies to date have been directed to the restoration of the dopaminergic system, and the prevention of dopaminergic neuronal cell death in the midbrain. This […]

The hippocampus features structurally and functionally distinct anterior and posterior segments. Relatively few studies have examined how these change during aging or in response to pharmacological interventions. Alterations in hippocampal connectivity and changes in glucose regulation have each been associated with cognitive decline in aging. A distinct line of research suggests that administration of glucose […]

Modality-invariant categorical representations, i.e., shared representation, is thought to play a key role in learning to categorize multi-modal information. We have investigated how a bimodal autoencoder can form a shared representation in an unsupervised manner with multi-modal data. We explored whether altering the depth of the network and mixing the multi-modal inputs at the input […]