Dysfunction in cholinergic modulation has been linked to a variety of cognitive disorders including Alzheimer’s disease. The important role of this neurotransmitter has been explored in a variety of experiments, yet many questions remain unanswered about the contribution of cholinergic modulation to healthy hippocampal function. To address this question, we have developed a model of […]

Excitation-inhibition (E-I) balanced neural networks are a classic model for modeling neural activities and functions in the cortex. The present study investigates the potential application of E-I balanced neural networks for fast signal detection in brain-inspired computation. We first theoretically analyze the response property of an E-I balanced network, and find that the asynchronous firing […]

Mild cognitive impairment (MCI) is a clinical state with a high risk of conversion to Alzheimer’s Disease (AD). Since there is no effective treatment for AD, it is extremely important to diagnose MCI as early as possible, as this makes it possible to delay its progression toward AD. However, it’s challenging to identify early MCI […]