Reactive oxygen species and reactive nitrogen species (RONS) are by-products of aerobic metabolism. RONS trigger a signaling cascade that can be transduced through oxidation-reduction (redox)-based post-translational modifications (redox PTMs) of protein thiols. This redox signaling is essential for normal cellular physiology and coordinately regulates the function of redox-sensitive proteins. It plays a particularly important role […]

Movement disorders are neurological conditions in which patients manifest a diverse range of movement impairments. Distinct structures within the basal ganglia of the brain, an area involved in movement regulation, are differentially affected for every disease. Among the most studied movement disorder conditions are Parkinson’s (PD) and Huntington’s disease (HD), in which the deregulation of […]

Is consciousness a continuous stream of percepts or is it discrete, occurring only at certain moments in time? This question has puzzled philosophers, psychologists, and neuroscientists for centuries. Both hypotheses have fallen repeatedly in and out of favor. Here, we review recent studies exploring long-lasting postdictive effects and show that the results favor a two-stage […]