Emotional appraisal in humans is often considered a centrally mediated process by which sensory signals, void of emotional meaning, are assessed by integrative brain structures steps removed from raw sensation. We review emerging evidence that the emotional value of the environment is coded by nonvisual sensory systems as early as the sensory receptors and that […]

Many cognitive and behavioral tasks—such as interval timing, spatial navigation, motor control, and speech—require the execution of precisely-timed sequences of neural activation that cannot be fully explained by a succession of external stimuli. We show how repeatable and reliable patterns of spatiotemporal activity can be generated in chaotic and noisy spiking recurrent neural networks. We […]

Dementia is a syndrome of acquired cognitive impairment that leads to a significant decline in a patient’s daily life, ability to learn, and the ability to communicate with others. Dementia occurs in many diseases, including Alzheimer’s disease (AD), dementia with Lewy bodies, frontotemporal dementia, and Parkinson’s disease dementia (PDD). Although the analysis of biomarkers in […]