Month: September 2023

Naturalistic reinforcement learning

Imagine being a master navigator, effortlessly maneuvering through a labyrinthine maze filled with countless choices and variables. That’s what humans excel at – making decisions in expansive, complex, and multidimensional real-world environments. While traditional studies on decision-making focused on artificial tasks, recent research takes a different approach. By incorporating naturalistic complexity into experimental paradigms, scientists […]

Published on September 30, 2023

Behavioral and neuropathological characterization over the adult lifespan of the human tau knock-in mouse

Tau is a microtubule-associated protein with a diverse functional repertoire linked to neurodegenerative disease. Recently, a human tau knock-in (MAPT KI) mouse was developed that may overcome many limitations associated with current animal models used to study tau. In MAPT KI mice, the entire murine Mapt gene was replaced with the human MAPT gene under […]

Published on September 29, 2023

How sleep quality affects activities of daily living in Parkinson’s disease: the mediating role of disease severity and the moderating role of cognition

ObjectiveThe aim of this study was to explore the influential mechanism of the relationship between sleep quality and activities of daily living (ADL) in patients with Parkinson’s disease (PD), we hypothesized disease severity as a mediator and assumed the mediating process was regulated by cognition.Methods194 individuals with PD (95 women and 99 men) were enrolled […]

Published on September 29, 2023