Imagine a conductor leading an orchestra, ensuring that every musician plays their part in harmony. The TAR DNA binding protein 43 kDa (TDP-43) plays a similar role in our cells, orchestrating essential functions. However, when TDP-43 goes awry, it can set off a chain reaction of dysfunction that may contribute to neurodegenerative diseases like ALS and […]
Published on March 9, 2023
Imagine a car that starts to have engine trouble before showing any other signs of wear and tear. In a similar fashion, scientists have observed that motor dysfunction, such as problems with movement and balance, often appear before other symptoms in patients with Alzheimer’s Disease (AD). However, the underlying mechanisms behind this phenomenon have remained […]
Published on March 9, 2023
The study explores the utility of new, advanced quantitative MRI metrics in brain ageing research. Like a high-resolution camera that captures intricate details, these MRI metrics allow scientists to evaluate various biological processes relevant to ageing in real time. By combining different MRI parameters, such as myelin density, cellular membrane integrity, and iron concentration, researchers […]
Published on March 9, 2023