Cognitive Science

The latest breakthroughs, innovations, and cool happenings at the cutting edge of the world of cognitive science. Updated daily.

Empirical mode decomposition of local field potential data from optogenetic experiments

IntroductionThis study investigated the effects of cocaine administration and parvalbumin-type interneuron stimulation on local field potentials (LFPs) recorded in vivo from the medial prefrontal cortex (mPFC) of six mice using optogenetic tools.MethodsThe local network was subject to a brief 10 ms laser pulse, and the response was recorded for 2 s over 100 trials for […]

Published on July 5, 2023

Cerebrospinal fluid microRNAs as potential biomarkers in Alzheimer’s disease

Alzheimer’s disease (AD) is the leading form of dementia worldwide, but its early detection and diagnosis remain a challenge. MicroRNAs (miRNAs) are a group of small endogenous RNA molecules that regulate mRNA expression. Recent evidence suggests miRNAs play an important role in the five major hallmarks of AD pathophysiology: amyloidogenesis, tauopathy, neuroinflammation, synaptic dysfunction, and […]

Published on July 5, 2023

O-GlcNAcylation regulates extracellular signal-regulated kinase (ERK) activation in Alzheimer’s disease

IntroductionAberrant activation of Extracellular Signal-Regulated Kinase (ERK) signaling is associated with Alzheimer’s disease (AD) pathogenesis. For example, enhanced ERK signal activation mediated by Apolipoprotein E4 (APOE4), which is a critical genetic risk factor for AD, increases the transcription of amyloid precursor protein (APP). We hypothesize that O-linked N-acetylglucosamine (O-GlcNAc) regulates the phosphorylation and activation of […]

Published on July 4, 2023