IntroductionFrailty is a geriatric syndrome frequently associated with executive dysfunction and white matter hyperintensities (WMH). But the relation between executive dysfunction and brain changes is poorly understood in frail subjects. Our hypothesis is that frontal-WMH mediates the association between frailty and executive dysfunction.MethodsA convenience sample of 113 subjects older than 65 years without dementia was […]
Published on August 30, 2023
BackgroundProgressive supranuclear palsy (PSP) is a clinically heterogenous atypical parkinsonian syndrome. Therefore, early recognition and correct diagnosis of PSP is challenging but essential. This study aims to characterize the clinical manifestations, magnetic resonance imaging (MRI), and longitudinal MRI changes of PSP in China.MethodClinical and MRI presentations were compared among 150 cases with PSP. Then the […]
Published on August 30, 2023
Understanding why the brain’s ability to adapt decreases with age is like figuring out why a rubber band loses its stretchiness over time. In this study, researchers delved into the genetic and epigenetic changes that occur in the supraoptic nucleus – a region responsible for regulating important brain functions. By analyzing the transcriptome (all the […]
Published on August 30, 2023
