Dementia remains one of the leading causes of morbidity and mortality in older adults. Alzheimer’s disease (AD) is the most common type of dementia, affecting over 55 million people worldwide. AD is characterized by distinct neurobiological changes, including amyloid-beta protein deposits and tau neurofibrillary tangles, which cause cognitive decline and subsequent behavioral changes, such as […]

BackgroundIn this study, we present a novel system for quantifying glutamine metabolism (GM) to enhance the effectiveness of Alzheimer’s disease (AD) diagnosis and risk prediction.MethodsSingle-cell RNA sequencing (scRNA-seq) analysis was utilized to comprehensively assess the expression patterns of GM. The WGCNA algorithm was applied to investigate the most significant genes related to GM. Subsequently, three […]

ObjectiveCoronary artery disease (CAD) usually coexists with subclinical cerebrovascular diseases given the systematic nature of atherosclerosis. In this study, our objective was to predict the progression of white matter hyperintensity (WMH) and find its risk factors in CAD patients using the coronary artery calcium (CAC) score. We also investigated the relationship between the CAC score […]