White matter hyperintensities (WMH) appear as regions of abnormally high signal intensity on T2-weighted magnetic resonance image (MRI) sequences. In particular, WMH have been noteworthy in age-related neuroscience for being a crucial biomarker for all types of dementia and brain aging processes. The automatic WMH segmentation is challenging because of their variable intensity range, size […]

Cognitive neuroscience has traditionally focused on simple tasks, presented sparsely and using abstract stimuli. While this approach has yielded fundamental insights into functional specialisation in the brain, its ecological validity remains uncertain. Do these tasks capture how brains function ‘in the wild’, where stimuli are dynamic, multimodal, and crowded? Ecologically valid paradigms that approximate real […]

Subclinical cerebrovascular disease is frequently identified in neuroimaging studies and is thought to play a role in the pathogenesis of cognitive disorders. However, the role of these neuroimaging findings in the context of normal cognitive aging is poorly understood. Identifying the etiologies of different types of lesions may help investigators differentiate between age-related and pathological […]