Amyloid hypothesis, the assumption that beta-amyloid toxicity is the primary cause of neuronal and synaptic loss, has been the mainstream research concept in Alzheimer’s disease for the past two decades. Currently, this model is quietly being replaced by a more holistic, “systemic disease” paradigm which, like the aging process, affects multiple body tissues and organs, […]

Sparse coding models of natural images and sounds have been able to predict several response properties of neurons in the visual and auditory systems. While the success of these models suggests that the structure they capture is universal across domains to some degree, it is not yet clear which aspects of this structure are universal […]

This article further develops a model of how reactive and planned behaviors interact in real time. Controllers for both animals and mobile robots, or animats, need reactive mechanisms for exploration, and learned plans to reach goal objects once an environment becomes familiar. Sequences of such behaviors need to be released at appropriate times during autonomous […]