Purpose: Predicting patient survival outcome is recognized as key importance to clinicians in oncology toward determining an ideal course of treatment and patient management. This study applies radiomics analysis on pre-operative multi-parametric MRI of patients with glioblastoma from multi-institution to identify a signature and a practical machine learning model for stratifying patients into groups based […]

Hallmarks of Alzheimer’s disease (AD) pathology include acetylcholine deficiency and plaque deposition. Emerging studies suggest that acetylcholinesterase (AChE) may interact with amyloid beta (Aβ) to promote aggregation of insoluble amyloid beta plaques in brains of patients. Current therapeutic options available for AD patients, such as AChE inhibitors, provide only symptomatic relief. In this study, we […]

Parkinson’s disease (PD) is a well-known neurodegenerative disease with a strong association established with systemic inflammation. Recently, the role of the gingipains protease group from Porphyromonas gingivalis was implicated in Alzheimer’s disease and here we present evidence, using a fluorescent antibody to detect gingipain R1 (RgpA), of it’s presence in a PD population. We confirm […]