Is consciousness a continuous stream of percepts or is it discrete, occurring only at certain moments in time? This question has puzzled philosophers, psychologists, and neuroscientists for centuries. Both hypotheses have fallen repeatedly in and out of favor. Here, we review recent studies exploring long-lasting postdictive effects and show that the results favor a two-stage […]

Kinases are an intensively studied drug target class in current pharmacological research as evidenced by the large number of kinase inhibitors being assessed in clinical trials. Kinase-targeted therapies have potential for treatment of a broad array of indications including central nervous system (CNS) disorders. In addition to the many variables which contribute to identification of […]

Alzheimer’s disease (AD) is a debilitating neurodegenerative disease characterized by the accumulation of two proteins in fibrillar form: amyloid-β (Aβ) and tau. Despite decades of intensive research, we cannot yet pinpoint the exact cause of the disease or unequivocally determine the exact mechanism(s) underlying its progression. This confounds early diagnosis and treatment of the disease. […]