Mild cognitive impairment (MCI) is a clinical state with a high risk of conversion to Alzheimer’s Disease (AD). Since there is no effective treatment for AD, it is extremely important to diagnose MCI as early as possible, as this makes it possible to delay its progression toward AD. However, it’s challenging to identify early MCI […]

Reactive oxygen species and reactive nitrogen species (RONS) are by-products of aerobic metabolism. RONS trigger a signaling cascade that can be transduced through oxidation-reduction (redox)-based post-translational modifications (redox PTMs) of protein thiols. This redox signaling is essential for normal cellular physiology and coordinately regulates the function of redox-sensitive proteins. It plays a particularly important role […]

Movement disorders are neurological conditions in which patients manifest a diverse range of movement impairments. Distinct structures within the basal ganglia of the brain, an area involved in movement regulation, are differentially affected for every disease. Among the most studied movement disorder conditions are Parkinson’s (PD) and Huntington’s disease (HD), in which the deregulation of […]