BackgroundDecreasing white matter integrity in limbic pathways including the fornix and cingulum have been reported in Alzheimer’s disease (AD), although underlying mechanisms and potential sex differences remain understudied. We therefore sought to explore sex as a moderator of the effect of age on myelin water fraction (MWF), a measure of myelin content, in older adults […]

ObjectiveTo examine complications and outcomes of hospitalizations for common indications for hospitalization among patients with Parkinson disease (PD).MethodsWe identified and selected the ten most common indications for hospitalization among individuals ≥65 years of age using principal diagnoses from the California State Inpatient Database, 2018–2020. Patients with comorbid PD were identified using secondary diagnosis codes and matched […]

Navigating the complex landscape of single-cell transcriptomic data presents significant challenges. Central to this challenge is the identification of a meaningful representation of high-dimensional gene expression patterns that sheds light on the structural and functional properties of cell types. Pursuing model interpretability and computational simplicity, we often look for a linear transformation of the original […]