Goal-driven deep learning increasingly supplements classical modeling approaches in computational neuroscience. The strength of deep neural networks as models of the brain lies in their ability to autonomously learn the connectivity required to solve complex and ecologically valid tasks, obviating the need for hand-engineered or hypothesis-driven connectivity patterns. Consequently, goal-driven models can generate hypotheses about […]

The main olfactory bulb is the key element of the olfactory pathway of rodents. To precisely dissect the neural pathway in the main olfactory bulb (MOB), it is necessary to construct the three-dimensional morphologies of the anatomical structures within it with micro-level resolution. However, the construction remains challenging due to the complicated shape of the […]

BackgroundThe course of impulse control disorders (ICD) varies in the early stage of Parkinson’s disease (PD).AimWe aimed to delineate the association between the evolution pattern of ICD and the progression of PD.MethodsA total of 321 de novo PD patients from the Parkinson’s Progression Markers Initiative database were included. Patients were followed up for a mean […]