The researchers measured an enzyme that breaks down a molecule often called the brain’s feel-good chemical. Higher enzyme levels mean less of that molecule is available to soothe circuits that manage emotion. The pattern showed up in people who used both substances, offering a biological clue for why co-users report more anxiety and greater difficulty quitting than people who use only one or neither.
For anyone interested in mental health, addiction, or how everyday choices influence brain chemistry, this study points to an important pathway connecting social behavior with biological change. Read the full article to see how these findings might shape support for people trying to reduce harm and strengthen recovery, and to learn what this could mean for inclusive, evidence-based approaches to wellbeing.
Scientists found that people who use both cannabis and tobacco show a distinct brain pattern tied to mood and stress regulation. Their scans revealed higher levels of an enzyme that reduces a natural feel-good molecule in the brain. This imbalance may help explain why co-users experience more anxiety and struggle more when quitting.
