Executive control fluctuations underlie behavioral variability in anthropoids

Published on November 19, 2024

In complex tasks requiring cognitive control, humans show trial-by-trial alterations in response time (RT), which are evident even when sensory-motor or other contextual aspects of the task remain stable. Exaggerated intra-individual RT variability is associated with brain injuries and frequently seen in aging and neuropsychological disorders. In this opinion, we discuss recent electrophysiology and imaging studies in humans and neurobiological studies in monkeys that indicate RT variability is linked with executive control fluctuation and that prefrontal cortical regions play essential, but dissociable, roles in such fluctuation of control and the resulting behavioral variability. We conclude by discussing emerging models proposing that both extremes of behavioral variability (significantly higher or lower) might reflect aberrant alterations in various aspects of decision-making processes.

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