Cracking the Code of the Brain’s Inhibitory Control

Published on October 27, 2023

Imagine your brain as a symphony orchestra, with different sections responsible for motor skills, memory, attention, and more. Just like a successful performance requires a conductor to keep all the musicians in sync, your brain needs inhibitory control to regulate and coordinate these various functions. Recent research has shown that inhibitory control is not limited to specific domains but is a general mechanism that operates across different cognitive processes. This discovery was made by investigating the shared neural signatures involved in inhibitory control across domains. The findings suggest that a specific mechanism involving the interplay between the frontal cortex and subthalamic region of the brain, known as the fronto-subthalamic mechanism, plays a crucial role in inhibitory control. By modulating thalamocortical drive in the β band frequency, this mechanism helps regulate and fine-tune cognitive processes in the human brain. Understanding how this domain-general mechanism functions opens up exciting possibilities for enhancing cognitive flexibility and behavior regulation.

Inhibitory control is a fundamental mechanism underlying flexible behavior and features in theories across many areas of cognitive and psychological science. However, whereas many theories implicitly or explicitly assume that inhibitory control is a domain-general process, the vast majority of neuroscientific work has hitherto focused on individual domains, such as motor, mnemonic, or attentional inhibition. Here, we attempt to close this gap between by highlighting recent work that demonstrates shared neuroanatomical and neurophysiological signatures of inhibitory control across domains. We propose that the regulation of thalamocortical drive by a fronto-subthalamic mechanism operating in the β band might be a domain-general mechanism for inhibitory control in the human brain.

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