Smelling for Trouble: Finding Prions in the Olfactory Mucosa

Published on February 27, 2023

Scientists have developed a new method, called the PMCA-based detection, to locate prions in the olfactory mucosa of patients with sporadic Creutzfeldt–Jakob disease (sCJD). Prions are misfolded proteins that can cause fatal neurodegenerative diseases. Like bloodhounds sniffing out a scent, researchers used this technique to track down prions in the nasal cavity, specifically in the olfactory mucosa. This discovery is significant because it suggests that prions can be present in easily accessible tissues and opens up a new pathway for early diagnostic tools. The olfactory mucosa could act as a ‘canary in the coal mine’, giving us an early warning sign of prion diseases. This finding also supports the idea that prions can potentially spread through the respiratory route, which raises concerns about disease transmission. Further research is needed to understand the implications of these findings and to develop effective prevention and treatment strategies. To learn more about this groundbreaking study, check out the full article!

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