The hormonal fluctuations of pregnancy, birth, and lactation initiate rapid and extreme physiological transformations that are unparalleled across the lifespan. These biological changes are accompanied by a dynamic restructuring of the physical, emotional, and social environment. In concert with these adaptations, the maternal brain undergoes significant structural and functional neuroplasticity [1,2] as well as cognitive adaptations [3] across the peripartum period (see Glossary). The brain is transformed, in preparation for and in response to, a developing child.