Picture this: it’s like a stormy night and you’re running out of candles just as the power goes out. That’s how health systems and pharmacies are feeling as they scramble to find enough antibiotics, antivirals, and pediatric cold and flu drugs. With the worst flu season in more than a decade, coupled with rising COVID-19 and RSV cases, the demand is skyrocketing. But the supply? Well, it’s trickling down to almost nothing. We’re now facing a ‘Tripledemic’ and not just any medications will do the trick. Antibiotics like amoxicillin, which fight bacterial infections; antivirals that target viruses; and pediatric cold and flu medicines are crucial for treating patients. It’s a race against time to ensure that the right medications reach those in need. To navigate this stormy situation, let’s explore the underlying research on drug shortages, potential solutions, and strategies to prioritize care.