Imagine you’re rearranging your kitchen and trying to figure out the best layout. You want to know if moving the toaster closer to the knives could potentially cause more accidents. In a similar vein, researchers investigated the relationship between subjective cognitive decline (SCD) and postoperative delirium (POD) in patients undergoing total hip replacement. They found that patients with SCD were more likely to develop POD, and SCD acted as a mediator for the occurrence of POD through a biomarker called P-tau in cerebrospinal fluid (CSF). The study involved collecting CSF samples from 1,471 patients and analyzing biomarkers using enzyme-linked immunosorbent assays. Logistic regression and sensitivity analyses confirmed that SCD and P-tau were risk factors for POD, with P-tau partially mediating the relationship between SCD and POD. Age, sleep quality, and higher levels of P-tau were also identified as risk factors for SCD. These findings suggest that addressing SCD and specifically targeting P-tau levels may help mitigate the occurrence of POD in patients undergoing total hip replacement. For more details, check out the full research article.

ObjectiveWe again investigated the relationship between subjective cognitive decline (SCD) and postoperative delirium (POD) with a larger sample queue. We also determined whether SCD could cause the occurrence of POD through cerebrospinal fluid (CSF) biomarkers.MethodsA prospective, observational cohort study was implemented in the Qingdao Municipal Hospital Affiliated with Qingdao University. This study recruited 1,471 qualified patients affiliated with the Perioperative Neurocognitive Disorder And Biomarker Lifestyle (PNDABLE) study scheduled for total hip replacement under combined spinal and epidural anesthesia from June 2020 to May 2022. The Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) were used to assess the cognitive level of the patients the day before surgery. Pittsburgh sleeps quality index (PSQI) scale was used to assess sleep status. Patients were divided into the SCD group and the non-SCD (NSCD) group based on the Subjective Cognitive Decline Scale (SCDS). CSF was collected after a successful spinal-epidural combined puncture, and amyloid-β40 (Aβ40), amyloid-β42 (Aβ42), total tau (T-tau), and phosphorylated tau (P-Tau) in CSF were analyzed by enzyme-linked immunosorbent assays. After the surgery, the incidence of POD was determined by the Confusion Assessment Scale (CAM), and Memorial Delirium Assessment Scale (MDAS) score was used to determine the severity of POD. Logistic regression and sensitivity analyses were performed to determine the relationship between CSF biomarkers, SCD, and POD. The mediating effect was used to analyze the function of specific CSF biomarkers in the relationship between SCD and POD. The risk factors of SCD were also separately verified by logistic regression and sensitivity analysis models.ResultsThe total incidence rate of POD was 19.60% (n = 225/1148), which was 29.3% (n = 120/409) in the SCD group and 14.2% (n = 105/739) in the NSCD group. We comprehensively considered the effect of covariates such as age, hypertension, and diabetes. Multivariate logistic regression analysis showed that SCD (OR = 1.467, 95%CI: 1.015–2.120, p = 0.042) and P-tau (OR = 1.046, 95%CI: 1.028–1.063, p < 0.001) were risk factors for POD. The sensitivity analysis results were consistent with the above results. Mediation analysis showed that the relationship between SCD and POD was partially mediated by P-tau, which accounted for 31.25% (P-tau, IE = 4.279 × 10−2, p < 0.001). For SCD, the results of logistic regression analysis models showed that age (OR = 1.035, 95% CI: 1.020–1.049, p < 0.001), higher preoperative PSQI score (OR = 1.047, 95%CI: 1.014–1.080, p = 0.005), and P-tau (OR = 1.015, 95%CI: 1.002–1.028, p = 0.021) were risk factors for SCD, and subsequent sensitivity analysis confirmed this result after adjustment for ASA grade, height, and weight.ConclusionPatients with SCD are more likely to develop POD undergoing total hip replacement, and SCD can mediate the occurrence of POD via P-tau.Clinical trial registrationThis study was registered at China Clinical Trial Registry (Chictr2000033439).

Read Full Article (External Site)