Brain patterns remain consistent throughout adulthood

Published on October 13, 2022

Think of the brain as a concert hall, with different musicians playing their instruments. This research aimed to explore how the musicians (specifically, the hand muscles) are represented in the brain’s symphony. Using a technique called transcranial magnetic stimulation (TMS), scientists examined two hand muscles in a group of right-handed individuals spanning various adult ages. They looked at factors like lateralization (how much one hemisphere is dominant) and distinctiveness (how separate the representations of different hand muscles are) within the brain. Surprisingly, no significant age-related differences were found! It seems that these brain patterns remain consistent as we grow older, like the musicians hitting all the right notes night after night. The study also measured dexterity and maximum force levels, but no correlations were identified with age or the TMS measures. This suggests that our brain’s musical arrangement remains rock-steady throughout adulthood. Now, let’s dive deeper into this fascinating research and explore the full article!

This study aimed to investigate the presence and patterns of age-related differences in TMS-based measures of lateralization and distinctiveness of the cortical motor representations of two different hand muscles. In a sample of seventy-three right-handed healthy participants over the adult lifespan, the first dorsal interosseus (FDI) and abductor digiti minimi (ADM) cortical motor representations of both hemispheres were acquired using transcranial magnetic stimulation (TMS). In addition, dexterity and maximum force levels were measured. Lateralization quotients were calculated for homolog behavioral and TMS measures, whereas the distinctiveness between the FDI and ADM representation within one hemisphere was quantified by the center of gravity (CoG) distance and cosine similarity. The presence and patterns of age-related changes were examined using linear, polynomial, and piecewise linear regression. No age-related differences could be identified for the lateralization quotient of behavior or cortical motor representations of both intrinsic hand muscles. Furthermore, no evidence for a change in the distinctiveness of the FDI and ADM representation with advancing age was found. In conclusion this work showed that lateralization and distinctiveness of cortical motor representations, as determined by means of TMS-based measures, remain stable over the adult lifespan.

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