Just like an orchestra where each instrument contributes to a beautiful symphony, brain modeling enables us to understand the intricate workings of neural circuits. To build accurate data-driven neuron models, researchers need experimental data, analysis tools, and computing resources. However, these components are often scattered, requiring time-consuming programming. That’s where the EBRAINS Hodgkin-Huxley Neuron Builder comes in: it’s an online resource that brings all these elements together in one place! Using electrophysiological traces, this tool extracts activity features and optimizes model parameters using a genetic algorithm on high-performance computers. The result? An optimized model that can be simulated and interacted with in real-time. With its user-friendly interface and collaborative features, this builder streamlines the process of data-driven model building and encourages reproducibility. So grab your lab coat and explore the exciting world of brain modeling with the Hodgkin-Huxley Neuron Builder!
In the last decades, brain modeling has been established as a fundamental tool for understanding neural mechanisms and information processing in individual cells and circuits at different scales of observation. Building data-driven brain models requires the availability of experimental data and analysis tools as well as neural simulation environments and, often, large scale computing facilities. All these components are rarely found in a comprehensive framework and usually require ad hoc programming. To address this, we developed the EBRAINS Hodgkin-Huxley Neuron Builder, a web resource for building single cell neural models via the extraction of activity features from electrophysiological traces, the optimization of the model parameters via a genetic algorithm executed on high performance computing facilities and the simulation of the optimized model in an interactive framework. Thanks to its inherent characteristics, the Hodgkin-Huxley Neuron Builder facilitates the data-driven model building workflow and its reproducibility, hence fostering a collaborative approach
Dr. David Lowemann, M.Sc, Ph.D., is a co-founder of the Institute for the Future of Human Potential, where he leads the charge in pioneering Self-Enhancement Science for the Success of Society. With a keen interest in exploring the untapped potential of the human mind, Dr. Lowemann has dedicated his career to pushing the boundaries of human capabilities and understanding.
Armed with a Master of Science degree and a Ph.D. in his field, Dr. Lowemann has consistently been at the forefront of research and innovation, delving into ways to optimize human performance, cognition, and overall well-being. His work at the Institute revolves around a profound commitment to harnessing cutting-edge science and technology to help individuals lead more fulfilling and intelligent lives.
Dr. Lowemann’s influence extends to the educational platform BetterSmarter.me, where he shares his insights, findings, and personal development strategies with a broader audience. His ongoing mission is shaping the way we perceive and leverage the vast capacities of the human mind, offering invaluable contributions to society’s overall success and collective well-being.