Imagine you’re exploring a vast safari and you stumble upon a hidden treasure map. In this case, the map is a bibliometric analysis of research on neuroinflammation-induced mild cognitive impairment (MCI). MCI is like a bridge between normal aging and dementia, and scientists believe that neuroinflammation in the brain plays a major role in its development. However, many of the details regarding the underlying mechanisms remain uncharted territory. This study aims to create an insightful visual model that maps out the articles published in this field over the past 11 years, revealing exciting hotspots of research and predicting future trends. By analyzing high-frequency keywords and co-cited reference bursts, researchers can gain valuable insights into the current status and potential future directions of this fascinating area of study. So, grab your metaphorical binoculars and join me in exploring this dynamic landscape of neuroinflammation-induced MCI. Who knows what groundbreaking discoveries lie ahead?

BackgroundMild cognitive impairment (MCI) is a precursor to dementia, and neuroinflammation in the brain is thought to be one of the main pathogenic mechanisms of MCI. However, the underlying neurobiological mechanisms have not been fully explored. The purpose of this study was to establish a visual model map of the articles in the field of neuroinflammation-induced MCI over the past 11 years to reveal the research hotspots and predict the future development trends in this field, which will help to promote the research and development for MCI.MethodsThe “neuroinflammation” and “mild cognitive impairment” were used as search terms, and literature about neuroinflammation-induced MCI published between 2011 and 2021 was collected from the Web of Science. CiteSpace and VOSviewer were used to create visual model maps, and assess collaboration among different authors, countries, and institutions. Finally, the current research hotspots and future research directions were analyzed by using high-frequency keywords analysis and co-cited reference burst analysis.ResultsA total of 226 articles were retrieved. The number of publications in neuroinflammation-induced MCI shows an upward trend. Since 2018, the number of papers published in this field has increased significantly, with an average of more than 100 published each year. The United States had the highest literature production and the number of cited journals in this research area, and the National Institute on Aging was the most productive research institution. Brooks D.J. and Heneka M.T. had the highest number of publications and had the highest frequency of co-citations. The co-cited references revealed the evolution of the research themes, and the current studies are mainly focused on the effects of various metabolites on the control of microglial activation. “Cerebrospinal fluid,” “mouse model,” “tau,” “microglial activation,” “astrocytes,” and “TREM2” were the current high-frequency and emerging keywords.ConclusionResearch on neuroinflammation-induced MCI is burgeoning, and the close collaboration with different nations and institutions need to be further strengthened. Current research hotspots are focused on the effects of various metabolites on microglia activation. Future studies should focus on how to regulate the phenotypes of microglia and astrocyte to reduce neuroinflammation and treat MCI.

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