Just like a contagion spreading from person to person, mis-folded tau proteins in the brain can propagate and worsen neurodegenerative diseases such as Alzheimer’s. Unlike amyloid plaques that appear throughout the brain at the same time, tau pathology starts in one specific region and then spreads to connected areas, contributing to disease progression. To stop this transmission, researchers are exploring ways to prevent mis-folded tau from moving between neurons. Recent studies have uncovered various cellular mechanisms involved in the secretion and uptake of tau, shedding light on potential therapeutic strategies. Additionally, these studies have identified tau-trafficking receptors, which play a role in either eliminating tau aggregates or facilitating their transmission between cells. Understanding these processes could lead to new treatments that slow down or halt the progression of neurodegenerative disorders. Learn more about this fascinating research by diving into the full article!
Neuronal accumulation of mis-folded tau is the pathological hallmark of multiple neurodegenerative disorders, including Alzheimer’s disease. Distinct from amyloid plaques, which appear simultaneously throughout the brain, tau pathology develops first in a specific brain region and then propagates to neuroanatomically connected brain regions, exacerbating the disease. Due to the implication in disease progression, prevention of tau transmission is recognized as an important therapeutic strategy that can halt disease progression in the brain. Recently, accumulating studies have demonstrated diverse cellular mechanisms associated with cell-to-cell transmission of tau. Once transmitted, mis-folded tau species act as a prion-like seed for native tau aggregation in the recipient neuron. In this review, we summarize the diverse cellular mechanisms associated with the secretion and uptake of tau, and highlight tau-trafficking receptors, which mediate tau clearance or cell-to-cell tau transmission.
Dr. David Lowemann, M.Sc, Ph.D., is a co-founder of the Institute for the Future of Human Potential, where he leads the charge in pioneering Self-Enhancement Science for the Success of Society. With a keen interest in exploring the untapped potential of the human mind, Dr. Lowemann has dedicated his career to pushing the boundaries of human capabilities and understanding.
Armed with a Master of Science degree and a Ph.D. in his field, Dr. Lowemann has consistently been at the forefront of research and innovation, delving into ways to optimize human performance, cognition, and overall well-being. His work at the Institute revolves around a profound commitment to harnessing cutting-edge science and technology to help individuals lead more fulfilling and intelligent lives.
Dr. Lowemann’s influence extends to the educational platform BetterSmarter.me, where he shares his insights, findings, and personal development strategies with a broader audience. His ongoing mission is shaping the way we perceive and leverage the vast capacities of the human mind, offering invaluable contributions to society’s overall success and collective well-being.