Imagine building a complex jigsaw puzzle. You need different pieces from various sets, but they all have to fit together perfectly to create the whole picture. That’s similar to what scientists face when trying to model biological neural networks. They need to convert different types of data into parameters for neurons and synapses, while also accounting for unknown variables based on experimental observations. To make this process easier and more transparent, researchers have developed a web-based framework that supports collaborative model building for spiking neural networks (SNN). Using a data description commonly used in business software development, they organize and manage all the data attributes within a database system. This allows for easy registration, visualization, and traceability of information throughout the modeling process. The framework has been successfully tested in creating SNN models for various brain regions and species, helping researchers combine existing models with data from scientific papers. It also ensures data integrity, consistency, and comparisons across different species. The framework is even being employed to integrate anatomical and physiological datasets from the brain/MINDS project to model the marmoset brain. Explore this exciting research to learn more about how scientists are untangling the mysteries of neural networks!
In building biological neural network models, it is crucial to efficiently convert diverse anatomical and physiological data into parameters of neurons and synapses and to systematically estimate unknown parameters in reference to experimental observations. Web-based tools for systematic model building can improve the transparency and reproducibility of computational models and can facilitate collaborative model building, validation, and evolution. Here, we present a framework to support collaborative data-driven development of spiking neural network (SNN) models based on the Entity-Relationship (ER) data description commonly used in large-scale business software development. We organize all data attributes, including species, brain regions, neuron types, projections, neuron models, and references as tables and relations within a database management system (DBMS) and provide GUI interfaces for data registration and visualization. This allows a robust “business-oriented” data representation that supports collaborative model building and traceability of source information for every detail of a model. We tested this data-to-model framework in cortical and striatal network models by successfully combining data from papers with existing neuron and synapse models and by generating NEST simulation codes for various network sizes. Our framework also helps to check data integrity and consistency and data comparisons across species. The framework enables the modeling of any region of the brain and is being deployed to support the integration of anatomical and physiological datasets from the brain/MINDS project for systematic SNN modeling of the marmoset brain.
Dr. David Lowemann, M.Sc, Ph.D., is a co-founder of the Institute for the Future of Human Potential, where he leads the charge in pioneering Self-Enhancement Science for the Success of Society. With a keen interest in exploring the untapped potential of the human mind, Dr. Lowemann has dedicated his career to pushing the boundaries of human capabilities and understanding.
Armed with a Master of Science degree and a Ph.D. in his field, Dr. Lowemann has consistently been at the forefront of research and innovation, delving into ways to optimize human performance, cognition, and overall well-being. His work at the Institute revolves around a profound commitment to harnessing cutting-edge science and technology to help individuals lead more fulfilling and intelligent lives.
Dr. Lowemann’s influence extends to the educational platform BetterSmarter.me, where he shares his insights, findings, and personal development strategies with a broader audience. His ongoing mission is shaping the way we perceive and leverage the vast capacities of the human mind, offering invaluable contributions to society’s overall success and collective well-being.