The Locus Coeruleus: Brain’s Bow Shaping Neural Melodies

Published on April 23, 2022

Imagine the brain as a delicate violin, and the locus coeruleus (LC) as its skilled bow. Just as a bow shapes the sound of a violin, the LC shapes neural dynamics in the brain. It doesn’t dictate specific content, but rather influences the excitability and receptivity of neurons throughout. This review delves into the analogy of bowing techniques to firing modes in the LC and how they produce unique activity patterns in the rest of the brain. By understanding this complex interplay, we gain intuitive insights into how the LC coordinates adaptive neural dynamics. So, if you’re curious to immerse yourself in this symphony of scientific knowledge, go ahead and read the full article!

Neural dynamics are shaped and constrained by the projections of a small nucleus in the pons: the noradrenergic locus coeruleus (LC). Much like a bow to the brain’s violin, activity in the LC lacks content specificity, but instead dynamically shapes the excitability and receptivity of neurons across the brain. In this review, we explain how the style of the bowing technique, which is analogous to different firing modes in the LC, affects distinct activity patterns in the rest of the brain. Through this analogical lens, we provide intuitive insights into how the complex activity of the LC acts to coordinate adaptive neural dynamics.

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