Background: Elevated plasma total homocysteine (tHcy) level, a known risk factor for vascular disease, is reported to be an independent risk factor for cognitive impairment and Alzheimer’s disease (AD) in most studies. tHcy may also be associated with dementia with Lewy bodies (DLB).Objective: To investigate the association between plasma tHcy levels and DLB or AD.Methods: […]

Medial temporal lobe (MTL) atrophy is a key feature of Alzheimer’s disease (AD), however, it also occurs in typical aging. To enhance the clinical utility of this biomarker, we need to better understand the differential effects of age and AD by encompassing the full AD-continuum from cognitively unimpaired (CU) to dementia, including all MTL subregions […]

A recent study by Witvliet et al. reconstructed the entire brain connectome for eight Caenorhabditis elegans spanning from birth to adulthood and described how synapse changes shape the connectome topology during development. Their data suggest some convergent developmental principles in connectome maturation between C. elegans and humans. Read Full Article (External Site) Dr. David LowemannDr. […]