Cortical pyramidal neurons have a complex dendritic anatomy, whose function is an active research field. In particular, the segregation between its soma and the apical dendritic tree is believed to play an active role in processing feed-forward sensory information and top-down or feedback signals. In this work, we use a simple two-compartment model accounting for […]

There is a critical window for estrogen replacement therapy, beyond which estradiol (E2) fails to enhance cognition and N-methyl-D-aspartate (NMDA) receptor function, and E2-responsive transcription decreases. Much less attention has been given to the mechanism for closing of the critical window, which is thought to involve the decline in estrogen signaling cascades, possibly involving epigenetic […]

Goal-directed behaviour requires flexible prioritisation of relevant sensations in space and time. A recent paper by Denison et al. brings time into a canonical model of voluntary selective attention. We reflect on this breakthrough and consider the opportunities it offers for future research on the dynamic fabric of mind. Read Full Article (External Site) Dr. […]