Parkinson’s disease (PD) is a neurodegenerative disorder caused by loss of dopaminergic neurons in substantia nigra pars compacta (SNc). Although the exact cause of cell death is not clear, the hypothesis that metabolic deficiency is a key factor has been gaining attention in recent years. In the present study, we investigated this hypothesis using a […]

The aim of this study was to characterize the EEG alterations in inter-band interactions along the Alzheimer’s disease (AD) continuum. For this purpose, EEG background activity from 51 healthy control subjects, 51 mild cognitive impairment patients, 50 mild AD patients, 50 moderate AD patients, and 50 severe AD patients was analyzed by means of bispectrum. […]

Synapses are highly stochastic transmission units. A classical model describing this stochastic transmission is called the binomial model, and its underlying parameters can be estimated from postsynaptic responses to evoked stimuli. The accuracy of parameter estimates obtained via such a model-based approach depends on the identifiability of the model. A model is said to be […]