Recently DCNN (Deep Convolutional Neural Network) has been advocated as a general and promising modeling approach for neural object representation in primate inferotemporal cortex. In this work, we show that some inherent non-uniqueness problem exists in the DCNN-based modeling of image object representations. This non-uniqueness phenomenon reveals to some extent the theoretical limitation of this […]

Systems of coupled dynamical units (e.g., oscillators or neurons) are known to exhibit complex, emergent behaviors that may be simplified through coarse-graining: a process in which one discovers coarse variables and derives equations for their evolution. Such coarse-graining procedures often require extensive experience and/or a deep understanding of the system dynamics. In this paper we […]

Progressive accumulation of amyloid-β (Aβ) plaques in the brain is a characteristic pathological change in Alzheimer’s disease (AD). We previously found the expression of lipoprotein lipase (LPL) was increased in SH-SY5Y cells exposed to low-dose Aβ and decreased in cells with high-dose Aβ exposure, but the molecular mechanism is still unclear. Based on previous studies, […]