BACKGROUND: Aging population undergoing surgery are at risk of postoperative cognitive dysfunction (POCD). Exploring effective and reliable early predictor of POCD is essential to identify high-risk patients and make prospective decisions. The purpose of this study was to examine whether preoperative insulin resistance, is an independent predictor of POCD.
METHODS: A total of 124 aged 60 years older patients for gastrointestinal surgery were enrolled in a prospective observational clinical study. All participants completed a battery of neuropsychological tests before surgery and at 7 days afterwards. POCD was defined as a decline of at least 1.5 SD on two or more of neuropsychological tests. Plasma concentration of tumor necrosis factor α (TNF-α), C-reactive protein (CRP), and S-100β protein were measured. The status of insulin resistance was assessed by Homeostasis Model Assessment–Insulin Resistance (HOMA-IR). The relationship between HOMA-IR and POCD was assessed by Multivariable logistic regression models and the receiver operating characteristic curve.
