Arterial input function (AIF) is estimated from perfusion images as a basic curve for the calculus of hemodynamic variables used as surrogate markers of the vascular status of tissues. However, at present, identification of AIF is made manually leading by prior knowledge. We propose an automatic estimation of AIF in perfusion images, which is based on a multi-stream 3D CNN, which combined spatial and temporal features together to estimate AIF ROI. The model is trained by manual annotations. The proposed method was trained and tested by 100 cases of PWI images. The result was evaluated by dice similarity coefficient (DSC), which reached to 0.79. The trained model had a better performance than the traditional method. After segmentation of AIF ROI, AIF was calculated by average of all voxels in ROI. We compared AIF result with manual and traditional method, and father process parameter maps such as Tmax and rCBF. The result had a better performance. We had applied the method on a cloud platform Estroke, which can evaluation ischemic penumbra to help make treatment decision.
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Dr. David Lowemann, M.Sc, Ph.D., is a co-founder of the Institute for the Future of Human Potential, where he leads the charge in pioneering Self-Enhancement Science for the Success of Society. With a keen interest in exploring the untapped potential of the human mind, Dr. Lowemann has dedicated his career to pushing the boundaries of human capabilities and understanding.
Armed with a Master of Science degree and a Ph.D. in his field, Dr. Lowemann has consistently been at the forefront of research and innovation, delving into ways to optimize human performance, cognition, and overall well-being. His work at the Institute revolves around a profound commitment to harnessing cutting-edge science and technology to help individuals lead more fulfilling and intelligent lives.
Dr. Lowemann’s influence extends to the educational platform BetterSmarter.me, where he shares his insights, findings, and personal development strategies with a broader audience. His ongoing mission is shaping the way we perceive and leverage the vast capacities of the human mind, offering invaluable contributions to society’s overall success and collective well-being.