Background and Purpose：This study aimed to investigate whether insulin resistance (IR) was associated with overall cerebral small vessel disease (CSVD) burden, independent of other clinical risk factors in old nondiabetic healthy subjects.
Methods: We recruited old nondiabetic healthy subjects with no taking any medications prospectively. The overall effect of CSVD on the brain was described by validated CSVD score. The homeostasis model assessment–estimated insulin resistance index(HOMA-IR) was used for IR estimation, and HOMA-IR ≥2.80 was defined as IR. We evaluated the association between IR and increasing severity of CSVD score by ordinal regression models, adjusted for demographics and cardiovascular risk factors.
Results: Our study included 156 healthy participants. 34 showed IR, 122 showed non-IR. The mean age of the IR group was older than non-IR group(70.03± 7.30 versus 67.45 ±5.92, p=0.04), and the ratio of hypertension in IR was higher than non-IR.( 53.28% versus 82.35%, p
