Background: Abnormalities of cognitive and movement functions are widely reported in Parkinson’s disease (PD). The mechanisms therein are complicated and assumed to a coordination of various brain regions. This study explored the alterations of global synchronizations of brain activities and investigated the neural correlations of cognitive and movement function in PD patients.
Methods: Age-match of 35 patients with PD and 35 normal controls (NC) were enrolled in resting-state functional magnetic resonance imaging (fMRI) scanning. Degree centrality (DC) were calculated to measure the global synchronizations of brain activity for two groups. Neural correlations between DC and cognitive function (Frontal Assessment Battery, FAB) as well as movement function (Unified Parkinson’s Disease Rating Scale, UPDRS-III) were examined across the whole brain within Anatomical Automatic Labeling (AAL) templates.
Results: In PD group, increased DC was observed in left fusiform gyrus extending to inferior temporal gyrus, left middle temporal gyrus and angular gyrus, while it was decreased in right inferior opercular-frontal gyrus extending to superior temporal gyrus. The DC in significant region of fusiform gyrus was positively correlated with UPDRS-III scores in PD (r = 0.41, p = 0.0145). Higher FAB scores were shown in NC than PD (p
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Dr. David Lowemann, M.Sc, Ph.D., is a co-founder of the Institute for the Future of Human Potential, where he leads the charge in pioneering Self-Enhancement Science for the Success of Society. With a keen interest in exploring the untapped potential of the human mind, Dr. Lowemann has dedicated his career to pushing the boundaries of human capabilities and understanding.
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