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A genetic mutation in amyotrophic lateral sclerosis (ALS) fibroblasts has been found to cause significant changes in the cells’ metabolic profile. The study identifies a specific truncation of the TDP43 protein as the culprit behind these alterations. Comparing the cells with the mutation to healthy cells, researchers observed differences in levels of pyruvate and intermediates […]
Imagine your brain as a bustling city, with lots of activity and communication happening all the time. But what happens when there’s an accident, like a stroke, that disrupts the flow of traffic? Well, it turns out that not only do the roads get blocked, but the local authorities – the immune cells and inflammation […]
Imagine a grand mansion where different rooms represent various aspects of Alzheimer’s disease (AD). One room explores the connection between sex differences and AD, while another delves into the impact of depression. In this study, researchers took a closer look at these rooms to gain a deeper understanding of how they interact. By comparing a […]
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