IntroductionAberrant activation of Extracellular Signal-Regulated Kinase (ERK) signaling is associated with Alzheimer’s disease (AD) pathogenesis. For example, enhanced ERK signal activation mediated by Apolipoprotein E4 (APOE4), which is a critical genetic risk factor for AD, increases the transcription of amyloid precursor protein (APP). We hypothesize that O-linked N-acetylglucosamine (O-GlcNAc) regulates the phosphorylation and activation of […]
Published on July 4, 2023
BackgroundStroke is a debilitating disease affecting millions of people worldwide. Despite the survival rate has significantly increased over the years, many stroke survivors are left with severe impairments impacting their quality of life. Rehabilitation programs have proved to be successful in improving the recovery process. However, a reliable model of sensorimotor recovery and a clear […]
Published on July 4, 2023
Imagine a grand symphony where every instrument plays harmoniously to create a beautiful piece of music. Just like that, scientists are working tirelessly to fine-tune new technologies that will detect, monitor, and treat Parkinson’s disease. Similar to a skilled conductor, these advancements coordinate multiple aspects of Parkinson’s management to provide a seamless and effective approach. […]
Published on July 4, 2023
