BackgroundIntracytoplasmic inclusions comprised of aggregated alpha-synuclein (αsyn) represent a key histopathological feature of neurological disorders collectively termed “synucleinopathies,” which includes Parkinson’s disease (PD). Mutations and multiplications in the SNCA gene encoding αsyn cause familial forms of PD and a large body of evidence indicate a correlation between αsyn accumulation and disease. Decreasing αsyn expression is […]
Published on August 10, 2023
Imagine your brain as a bustling city, with different areas communicating with each other through frequencies. Well, scientists have discovered that these frequencies can reveal how our brain decodes social rewards! Just like deciphering secret codes, the brain uses distinct coordination frequencies to distinguish between vicarious reward (observing someone else being rewarded) and experienced reward […]
Published on August 10, 2023
Imagine the striatum (a brain region) as a bustling city. The mayor of this city is called Rhes, who has an important job in maintaining order and balance. But in Huntington’s disease (HD), trouble arises when mutant huntingtin (a harmful protein) starts piling up in the city. Our study shows that when we knock down […]
Published on August 10, 2023
