Cognitive Science

The latest breakthroughs, innovations, and cool happenings at the cutting edge of the world of cognitive science. Updated daily.

Behavioral and neuropathological characterization over the adult lifespan of the human tau knock-in mouse

Tau is a microtubule-associated protein with a diverse functional repertoire linked to neurodegenerative disease. Recently, a human tau knock-in (MAPT KI) mouse was developed that may overcome many limitations associated with current animal models used to study tau. In MAPT KI mice, the entire murine Mapt gene was replaced with the human MAPT gene under […]

Published on September 29, 2023

How sleep quality affects activities of daily living in Parkinson’s disease: the mediating role of disease severity and the moderating role of cognition

ObjectiveThe aim of this study was to explore the influential mechanism of the relationship between sleep quality and activities of daily living (ADL) in patients with Parkinson’s disease (PD), we hypothesized disease severity as a mediator and assumed the mediating process was regulated by cognition.Methods194 individuals with PD (95 women and 99 men) were enrolled […]

Published on September 29, 2023

Differential spatiotemporal gait effects with frequency and dopaminergic modulation in STN-DBS

Imagine Parkinson’s disease as a symphony, with the brain as the conductor. In this magnificent performance, the dancers, our lower limbs, showcase their moves in a beautifully choreographed gait. However, sometimes the dancers stumble, and that’s where deep brain stimulation (STN-DBS) and medication step in as backup dancers to help them regain their grace. A […]

Published on September 29, 2023