Alzheimer’s disease (AD) is reportedly associated with the accumulation of calcium ions (Ca2+), and this accumulation is responsible for the phosphorylation of tau. Although several lines of evidence demonstrate the above phenomenon, the inherent mechanisms remain unknown. Using APP/PS1 Tg mice and neuroblastoma (N)2a cells as in vivo and in vitro experimental models, we observed […]

We aimed to evaluate the effect of multi-ingredient nutritional supplementation, with and without exercise training, on cognitive function in healthy older men. Forty-nine sedentary men (age: 73±6years [mean±SD]; body mass index: 28.5±3.6kg/m2) were randomized to consume a supplement (SUPP n=25; 1500mg n-3 polyunsaturated fatty acids, 30g whey protein, 2.5g creatine, 500IU vitamin D, and 400mg […]

Big Data promises to advance science through data-driven discovery. However, many standard lab protocols rely on manual examination, which is not feasible for large-scale datasets. Meanwhile, automated approaches lack the accuracy of expert examination. We propose to 1) start with expertly labelled data, 2) amplify labels through web applications that engage citizen scientists, and 3) […]