The process through which neurons are labeled is a key methodological choice in measuring neuron morphology. However little is known about how this choice may bias measurements. To quantify this bias we compare the extracted morphology of neurons collected from the same rodent species, experimental condition, gender distribution, age distribution, brain region and putative cell […]

Recent works have extensively investigated the possibility to predict brain aging from T1-weighted MRI brain scans. The main purposes of these studies are the investigation of subject-specific aging mechanisms and the development of accurate models for age prediction. Deviations between predicted and chronological age are known to occur in several neurodegenerative diseases; as a consequence, […]

Alzheimer’s disease (AD) has been associated with dysregulation of brain cholesterol homeostasis. Proprotein convertase subtilisin/kexin type 9 (PCSK9), beyond the known role in the regulation of plasma low-density lipoprotein cholesterol, was firstly identified in the brain with a potential involvement on brain development and apoptosis. However, its role in the central nervous system and in […]