The aging retinal pigment epithelium and oxidative stress, mediated by reactive oxygen species accumulation, have been implicated in the mechanisms of age-related macular degeneration (AMD). The expression level of the adapter protein p66shc, a key protein that regulates cellular oxidative stress, is relatively low under normal conditions because of the effects of silent mating type […]

Read Full Article (External Site) Dr. David LowemannDr. David Lowemann, M.Sc, Ph.D., is a co-founder of the Institute for the Future of Human Potential, where he leads the charge in pioneering Self-Enhancement Science for the Success of Society. With a keen interest in exploring the untapped potential of the human mind, Dr. Lowemann has dedicated […]

Background and Purpose：This study aimed to investigate whether insulin resistance (IR) was associated with overall cerebral small vessel disease (CSVD) burden, independent of other clinical risk factors in old nondiabetic healthy subjects. Methods: We recruited old nondiabetic healthy subjects with no taking any medications prospectively. The overall effect of CSVD on the brain was described […]