Cognitive function relies on the dynamic cooperation of specialized regions of the brain; however, the elements of the system responsible for coordinating this interaction remain poorly understood. In this Opinion article I argue that this capacity is mediated in part by competitive and cooperative dynamic interactions between two prominent metabotropic neuromodulatory systems – the cholinergic […]

Our knowledge of the brain has evolved over millennia in philosophical, experimental and theoretical phases. We suggest that the next phase is simulation neuroscience. The main drivers of simulation neuroscience are big data generated at multiple levels of brain organization and the need to integrate these data to trace the causal chain of interactions within […]

A growing body of evidence indicates that biomarkers of cardiovascular risk may be related to cerebral health. However, little is known about the role non-fasting lipoprotein play in assessing age-related declines in a cerebral biomarker sensitive to vascular compromise, white matter (WM) microstructure. High-density lipoprotein cholesterol (HDL-C) is atheroprotective and low-density lipoprotein cholesterol (LDL-C) is […]