Many neurodegenerative diseases manifest in an overall aged population, the pathology of which is hallmarked by abnormal protein aggregation. It is known that across aging, sleep quality becomes less efficient and protein homeostatic regulatory mechanisms deteriorate. There is a known relationship between extended wakefulness and poorly consolidated sleep and an increase in cellular stress. In […]

Intrinsic functional connectivity of large-scale brain networks has been shown to change with aging and Alzheimer’s disease (AD). These alterations are thought to reflect changes in synaptic function, but the underlying biological mechanisms are poorly understood. This study examined whether Neuronal Pentraxin 2 (NPTX2), a synaptic protein that mediates homeostatic strengthening of inhibitory circuits to […]

The current ‘one size fits all’ approach to our cognitive aging population is not adequate to close the gap between cognitive health span and lifespan. In this review paper, we present a a novel model for understanding, preventing, and treating age-related cognitive impairment (ARCI) based on the concepts precision medicine. We will discuss how multiple […]