The neurons of the olivocerebellar circuit exhibit complex electroresponsive dynamics, which are thought to play a fundamental role for network entraining, plasticity induction, signal processing and noise filtering. In order to reproduce these properties in single-point neuron models, we have optimized the Extended-Generalized Leaky Integrate and Fire (E-GLIF) neuron through a multi-objective gradient-based algorithm targeting […]

Typical cognitive load tasks are now known to deactivate the brain’s default-mode network (DMN). This raises the possibility that apparent effects of cognitive load could arise from disruptions of DMN processes, including social cognition. Cognitive load studies are reconsidered, with reinterpretations of past research and implications for dual-process theory. Read Full Article (External Site) Dr. […]

Amyloid-β (Aβ) deposition, neurofibrillary tangles induced by phosphorylation of tau protein and neuronal apoptosis are pathological hallmarks of Alzheimer’s disease (AD).The dementia rate in the alcoholic abusers were found to be higher than the control people. The present study explored potential roles of alcohol dehydrogenase 1B (ADH1B) in AD pathological process.The results showed that ADH1B […]