Activation of microglia, the primary mediators of inflammation in the brain, is a major component of gliosis and neuronal loss in a number of age-related neurodegenerative disorders, such as Alzheimer disease. The role of activated microglia in white matter, and its relationship to cognitive decline during aging, are unknown. The current study evaluated microglia densities […]

Literacy has many obvious benefits: it exposes the reader to a wealth of new information and enhances syntactic knowledge. However, we argue that literacy has an additional, often overlooked, benefit: it enhances people’s ability to predict spoken language thereby aiding comprehension. Readers are under pressure to process information more quickly than listeners and reading provides […]

Background. Increasingly favorable mortality prognosis in multiple sclerosis (MS) raises questions regarding MS-specific cognitive aging and the presence of comorbidities such as Alzheimer’s disease (AD). Objective. To assess elderly with MS (EwMS) and age-matched healthy controls (HCs) using both MS- and AD-specific psychometrics. Methods. EwMS (n=104) and 56 HCs were assessed on a broad spectrum […]